Publications

2025

  • Cassioli C, Capitani C, Staton CC, Schirra C, Finetti F, Onnis A, Alawar N, Tu S-M, Lopresti L, Tatangelo V, Tangredi C, Valvo S, Chang H-F, Miccoli A, Compeer EB, Nicholls J, Blazar B, Marotta G, Wood MJA, Trentin L, Patrussi L, Dustin ML, Becherer U, Baldari CT (2025) Activation-induced thrombospondin-4 works with thrombospondin-1 to build cytotoxic supramolecular attack particles. PNAS 122, e2413866122. doi: 10.1073/pnas.2413866122, Link

2024

  • Lopresti L, Tatangelo V, Baldari CT, Patrussi L (2024) Rewiring the T cell-suppressive cytokine landscape of the tumor microenvironment: a new frontier for precision anti-cancer therapy. Front Immunol 15, 1418527. doi: 10.3389/fimmu.2024.1418527,​ Link
  • Migliore L, Cianfanelli V, Zevolini F, Gesualdo M, Marzuoli L, Patrussi L, Ulivieri C, Marotta G, Cecconi F, Finetti F*, Baldari CT* (2024) An AMBRA1, ULK1 and PP2A regulatory network regulates cytotoxic T cell differentiation via TFEB activation. Sci Rep 14, 31838. doi: 10.1038/s41598-024-82957-9,​ Link
  • Boncompagni G, Tatangelo V, Lopresti L, Ulivieri C, Capitani N, Tangredi C, Marotta G, Frezzato F, Visentin A, Ciofini S, Gozzetti A, Calzada-Fraile D, Martin Cofreces NB, Trentin L, Patrussi L*, Baldari CT* (2024) Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia. Cell Death Dis 15,144. doi: 10.1038/s41419-024-06528-6. *shared senior authorship, Link
  • Montecchi T, Nannini G, De Tommaso D, Cassioli C, Monaci S, Coppola F, Ringressi MN, Naldini A, Taddei A, Marotta G, Amedei A*, Baldari CT*, Ulivieri C* (2024) Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK3 activation and PD-1 expression. Cancer Immunol Immunother 73, 2. doi: 10.1007/s00262-023-03614-0. *shared senior authorship, Link
  • Lopresti L, Capitani N, Tatangelo V, Boncompagni G, Frezzato F, Visentin A, Marotta G, Gozzetti A, Bocchia M, Trentin L, Baldari CT*, Patrussi L* (2024) p66Shc deficiency in CLL cells enhances PD-L1 expression and suppresses immune synapse formation. Front Cell Dev Biol 12, 1297116. *shared senior authorship, https://doi.org/10.3389/fcell.2024.1297116, Link
  • Alawar N, Schirra C, Hohmann M, Becherer U (2024) A solution for highly efficient electroporation of primary cytotoxic T lymphocytes. BMC Biotechnology 24, 16,  https://doi.org/10.1186/s12896-024-00839-4. Link
  • Zevolini F, Onnis A, Khazen R, Mueller S, Marotta G, Valitutti S, Finetti F, Baldari CT (2024) Polo-like kinase 1 regulates immune synapse assembly and cytotoxic T cell function by driving microtubule dynamics. J Cell Sci 137, jcs261476, https://doi.org/10.1242/jcs.261476, Link

2023

  • Baldari CT, Onnis A, Andreano E, Del Giudice G, Rappuoli R (2023) Emerging roles of SARS-CoV-2 Spike/ACE2 in immune evasion and pathogenesis. Trends Immunol 44, 424-434, https://doi.org/10.1016/j.it.2023.04.001.  Link
  • Capitani N, Cassioli C, Ravichandran K, Baldari CT (2023). Exploiting the RUSH system to study lytic granule biogenesis in CTLs. Methods Mol Biol. 2023; 2654: 421-436. doi: 10.1007/978-1-0716-3135-5_27 (The Immune Synapse: Methods and Protocols, Second Edition. ML Dustin & CT Baldari Eds.) Link
  • Chang HF, Schirra C, Pattu V, Krause E, Becherer U (2023) Lytic granule exocytosis at immune synapses: lessons from neuronal synapses. Front Immunol 14, doi: 10.3389/fimmu.2023.1177670
  • Cortacero K, McKenzie B, Müller S, Khazen R, Lafouresse F, Corsaut G, Van Acker N, Frenois F-X, Lamant L, Meyer N, Vergier B, Wilson DG, Luga H, Staufer S, Dustin ML, Valitutti S, Cussat-Blanc S (2023) Evolutionary design of explainable algorithms for biomedical image segmentation. Nat Commun 14, 7112. doi 10.1038/s41467-023-42664-x. Link
  • Cortacero K, McKenzie B, Müller S, Khazen K, Lafouresse F, Corsaut G, Van Acker N, Frenois FX, Lamant L, Meyer N, Vergier B, Wilson DG, Luga H, Staufer O, Dustin ML, Valitutti S, Cussat-Blanc S (2023) Kartezio: evolutionary design of explainable pipelines for biomedical image analysis. arXiv. 2302.14762. doi: 10.48550/arxiv.2302.14762. Link
  • Jainarayanan AK, Capera J, Céspedes PF, Conceição M, Elanchezhian M, Thomas T, Bonner S, Valvo S, Kurz E, Mahla RS, Berridge G, Hester S, Fischer R, Dustin LB, Wood MJA, Dustin ML (2023) Comparison of different methods for isolating CD8+ T lymphocyte-derived extracellular vesicles and supramolecular attack particles. Journal of Extracellular Biology 2, e74. doi: 10.1002/jex2.74. Link
  • Kvalvaag A, Valvo S, Céspedes PF, Saliba DG, Kurz E, Korobchevskaya K, Dustin ML (2023) Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse. PNAS 120 (6) e22113681; https://doi.org/10.1073/pnas.221136812, Link
  • McKenzie B, Valitutti S (2023) Resisting T cell attack: tumor-cell-intrinsic defense and reparation mechanisms. Trends in Cancer 9, 198-211. doi: 10.1016/j.trecan.2022.12.003. Link
  • Müller S, Filali L, Puissegur MP, Valitutti S (2023) Measuring CTL Lytic Granule Secretion and Target Cell Membrane Repair by Fluorescent Lipophilic Dye Uptake at the Lytic Synapse. Methods Mol Biol 2654: 463-476. doi: 10.1007/978-1-0716-3135-5_30, Link
  • Onnis A, Andreano E, Cassioli C, Finetti F, Della Bella C, Staufer O, Pantano E, Abbiento V, Marotta G, D’Elios MM, Rappuoli R, Baldari CT (2023). SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly. J Exp Med 220(2):e20220906. doi: 10.1084/jem.20220906, Link
  • Schirra C, Alawar N, Becherer U, Chang HF (2023) Separation of Single Core and Multicore Lytic Granules by Subcellular Fractionation and Immunoisolation. Methods Mol Biol. 2023;2654:159-167. doi: 10.1007/978-1-0716-3135-5_11, Link
  • Zec K, Schonfeldova B, Ai Z, Van Grinsven E, Pirgova G, Eames HL, Berthold DL, Attar M, Compeer EB, Arnon TI, Udalova IA (2023) Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation. Journal of Experimental Medicine 220, e20220595. doi: 10.1084/jem.20220595. Link

2022

  • Capitani N, Onnis A, Finetti F, Cassioli C, Plebani A, Brunetti J, Troilo A, D’Elios S, Baronio M, Gazzurelli L, Della Bella C, Billadeau D, D’Elios MM, Lougaris V, Baldari CT (2022) A CVID-associated variant in the ciliogenesis protein CCDC28B disrupts immune synapse assembly. Cell Death Differ 29, 65-81. doi: 10.1038/s41418-021-00837-5. Link
  • Capitani N, Baldari CT (2022) The Immunological Synapse: An Emerging Target for Immune Evasion by Bacterial Pathogens. Front Immunol 13: 943344. doi: 10.3389/fimmu.2022.943344, Link
  • Cassioli C, Baldari CT (2022) The expanding arsenal of cytotoxic T cells. Front Immunol, 20 April 2022. doi: 10.3389/fimmu.2022.883010 (Review) Link
  • Cassioli C, Baldari CT (2022) Lymphocyte polarization during immune synapse assembly: centrosomal actin joins the game. Front Immunol 13, 830835. doi: 10.3389/fimmu.2022.830835 (Review) Link
  • Cassioli C, Patrussi L, Valitutti S, Baldari CT (2022) Learning from TCR signaling and immunological synapse assembly to build new Chimeric Antigen Receptors (CARs). Int J Mol Sci 23, 14255; https://doi.org/10.3390/ijms232214255, Link
  • Chang HF, Schirra C, Ninov M, Hahn U, Ravichandran K, Krause E, Becherer U, Bálint Š, Harkiolaki M, Urlaub H, Valitutti S, Baldari CT, Dustin ML, Jahn R, Rettig J. (2022) Identification of distinct cytotoxic gran-ules as the origin of supramolecular attack particles in T lymphocytes. Nat Commun 13, 1029. doi: 10.1038/s41467-022-28596-y. Link
  • Finetti F, Onnis A, Baldari CT (2022) IFT20: An Eclectic Regulator of Cellular Processes beyond Intraflagellar Transport. Int J Mol Sci 23: 12147. doi: 10.3390/ijms232012147, Link
  • Filali L, Puissegur MP, Cortacero K, Cussat-Blanc S, Khazen R, Van Acker N, Frenois, FX, Abreu A, Lamant L, Meyer N, Vergier B, Müller S, McKenzie B and Valitutti S (2022) Ultra-rapid lytic granule release from CTL activates Ca2+-dependent synaptic resistance pathways in melanoma cell. Science Advances. 8, eabk3234. doi: 10.1126/sciadv.abk3234. Link
  • McKenzie B, Khazen R and Valitutti S (2022) Greek fire, poison arrows, and scorpion bombs: how tumor cells defend against the siege weapons of cytotoxic T lymphocytes. Front Immunol, 3 May 2022. doi: doi.org/10.3389/fimmu.2022.894306 (Review) Link
  • Tatangelo V, Boncompagni G, Capitani N, Lopresti L, Manganaro N, Frezzato F, Visentin A, Trentin L, Baldari CT, Patrussi L (2022) p66Shc deficiency in chronic lymphocytic leukemia promotes chemokine receptor expression through the ROS-dependent inhibition of NF-κB. Frontiers in Oncology 12, 877495. doi: 10.3389/fonc.2022.877495. Link

2021

  • Cassioli C, Onnis A, Finetti F, Capitani N, Brunetti J, Compeer EB, Niederlova V, Stepanek O, Dustin ML, Baldari CT (2021) The Bardet-Biedl Syndrome complex component BBS1 controls T cell polarity during immune synapse assembly. J Cell Sci 134, jcs258462. doi: 10.1242/jcs.258462. Link
  • Cassioli C, Balint S, Compeer EB, Felce JH, Gamberucci A, Della Bella C, Felce SJ, Brunetti J, Valvo S, Pende D, D’Elios MM, Moretta L, Dustin ML, Baldari CT (2021) Increasing LFA-1 expression enhances immune synapse architecture and T cell receptor signaling in Jurkat E6.1 cells. Front Cell Dev Biol 9, 673446. doi: 10.3389/fcell.2021.673446. Link