The fourth face-to-face meeting of our consortium took place in Toulouse, France, in October 2025. In addition to inspiring talk sessions and poster presentations by our members, we also had the honor of welcoming several guest speakers in person (Wolfgang Schamel / University of Freiburg, Germany; Audrey Gérard / University of Oxford, UK; Sylvain Cussat-Blanc / Toulouse Research Institute in Computer Science, France; Lorenzo Scipioni / Cancer Research Center of Toulouse, France) or virtually (Xiaohan Ning/Dana-Farber Cancer Institute, Boston, US ). Overall, the meeting successfully contributed to a synergistic collaboration in the areas of cytotoxic T cells, SMAPs, and beyond. We would like to thank all participants and especially this year’s main organizers, Salvatore Valitutti and Sabina Müller.